A full and comprehensive range of equipment is available in Selcia’s GLP / GMP analytical facility
High Field NMR Systems
Bruker DPX 300MHz
Fully automated for Open Access synthetic chemistry support.
Bruker DPX 400MHz & Bruker DRX 500MHz
Primary use in synthetic chemistry QC analysis, problem solving and structural elucidation.
The NMR systems can perform a wide range of experiments including the following:
Experiments
1H, 13C, 1H{15N}, 15N{1H}, 1H{19F}, 19F{1H}, 1H{31P}, 31P{1H}, 1H COSY, ed-HSQC, HMBC, nOesy, rOesy, , hsqc-tocsy(s), selective hmbc, 1H-15N hmbc, 1H gradient n.O.e(1D), 1H gradient selective tocsy(1D).
Flow-NMR Analysis (QC & High-throughput analyses)
LC-NMR Analysis (PrepLC followed by capillary NMR for for maximum sensitivity - metabolite & process-impurity analyses)
HR-MAS Analysis (gels, tissue samples, semi-solids)
Ligand Binding (STD-NMR)
Mass Spectrometer Systems
Waters ZQ LC-MS
Micromass Platform II LC-MS
Both fully automated for Open Access synthetic chemistry support
Micromass Quattro-LC-MS/MS
Primary use in Problem Solving, Structural Elucidation and PK analyses.
Thermo AQA LC-MS
Primary use in Synthetic Chemistry QC analysis.
HP / Agilent GC-MS
Primary use in routine analysis, problem solving and structural elucidation.
Analytical HPLC systems
Agilent Radio-LC
Primary used for routine QC analysis and to provide high quality HPLC data on radiolabelled and non-radiolabelled compounds.
Other Equipment in the Analytical GLP / GMP Facility
Nicolet FTIR
Primary use in GLP QC analysis.
LSC counter
Primary use QC and radiochemistry support.