Literature

New-Selcia White Paper available for download

Prolyl Isomerases -Old Proteins as New Therapeutic Targets
Prolyl isomerase inhibitors are an emerging class of drugs, acting on an unexploited class of therapeutic targets and representing a novel category of drugs acting by novel mechanisms.

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The following publications feature Selcia work or Selcia scientists as authors/co-authors:

 

  • Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A, Journal of Medicinal Chemistry, 2017, 60 (3), 1000–1017

  • The Discovery of Teixobactin L. Lazarides, J. Y. C. Chiva, M. Jones and V. A. Steadman.  Chapter 6: Antibiotic Drug Discovery: New Targets and Molecular Entities (Publisher RSC) 2017, p127-140.

  • Methods for Synthesizing Molybdopterin Precursor Z Derivatives, 2016 US Patent No. 9,260,462
  • Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency, Nature Communications doi:10.1038/ncomms12317 2016
  • Neurodegenerative diseases: the potential of cyclophilin inhibition, Drug Target Review, 2016 January
  • Total Radiosynthesis of [14C]Homoharringtonine, European Journal of Organic Chemistry 2015, 36, 8003-8010
  • Bifunctional crosslinking ligands for transthyretin, Open Biology 2015, doi: 10.1098/rsob. 150105
  • A new antibiotic kills pathogens without detectable resistance, Nature 2015, doi:10.1038/nature14098
  • Novel depsipeptide and use to treat infections. PCT Int. Appl. 2014, WO 2014089053 A1
  • Preparation of substituted hydrocarbyl-1H-pyrazole carboxylic acids at multiple prostaglandin receptors giving a general anti-inflammatory response PCT Int. Appl. 2014, WO 2014113814 A1
  • 14C-Labelling of the Acaricide Hexythiazox, 22nd International Isotope Society UK Group Symposium, 2013
  • A convergent stereocontrolled synthesis of [3-14C]Solanesol Journal of Labelled Compounds and Radiopharmaceuticals 2013, 56(9-10), 485–491
  • Macrocyclic inhibitors of flaviviridae viruses 2013 U.S. Pat Appl US 20130344029 A1
  • Preparation of substituted indole and indazole carboxylic acid derivatives as prostaglandin receptors antagonists PCT Int. Appl. 2013, WO 2013096496 A2
  • Preparation of N-substituted pyrazoles as prostaglandin receptors antagonists U.S. Pat. Appl. Publ. 2013, US 20130165666 A1
  • Preparation of substituted 1-benzyl-5-methyl-1H-pyrazole-5-carboxylic acid derivatives as prostaglandin receptors antagonists U.S. Pat. Appl. Publ. 2013, US 20130165492 A1
  • Preparation of substituted hydrocarbyl-1H-pyrazole carboxylic acids at multiple prostaglandin receptors giving a general anti-inflammatory response U.S. Pat. Appl. Publ. 2013, US 20130131135 A1
  • Preparation of macrocyclic peptides as inhibitors of flaviviridae viruses. PCT Int. Appl. 2013, WO 2013185093 A1
  • Preparation of macrocyclic peptides as inhibitors of flaviviridae viruses. PCT Int. Appl. 2013, WO 2013185103 A1
  • Preparation of cyclosporin A analogs as Cyclophilin A inhibitors for treating dry eye and other conditions. PCT Int. Appl. 2013, WO 2013181339 A2
  • Stabilised G protein-coupled receptors in structure-based drug design: a case study with adenosine A2A receptor Med. Chem. Comm. 2012 DOI: 10.1039/C2MD20164J
  • Fragment Screening Using Capillary Electrophoresis (CEfrag) for Hit Identification of Heat Shock Protein 90 ATPase Inhibitors J Biomol Screen May 9, 2012 doi 10.1177/1087057112445785
  • Finding the properties that make successful drugs, sp2 inter-active March/April 2012, 16-18
  • Screening Techniques for Fragment- Based Drug Discovery, Innovations in Pharmaceutical Technology, June 2012
  • Preparation of macrocyclic peptides as inhibitors of flaviviridae viruses for treating particularly hepatitis C infections. PCT Int. Appl. 2012, WO 2012078915 A1 20120614
  • Fatty acid amide hydrolase inhibitors for treating pain PCT Int. Appl. 2012, WO 2012162416 A1
  • Fatty acid amide hydrolase inhibitors for treating pain U.S. Pat. Appl. Publ. 2012, US 20120270915 A1
  • Preparation of N-alkyl{[substituted[oxo(trifluoromethylsulfonamido)propyl]benzyl}pyrrolidinyl)oxazole-4-carboxamide for treatment of DP1, FP, EP1, EP3, TP and/or EP4 receptor mediated diseases PCT Int. Appl. 2012, WO 2012024559 A1
  • Preparation of pyrazole compounds that act at multiple prostaglandin receptors giving a general anti-inflammatory response PCT Int. Appl. 2012, WO 2012003414 A1
  • Inhibition of inflammation by simultaneous blockade of multiple prostanoid receptors PCT Int. Appl. 2012, WO 2012003477 A2
  • Without a Trace-(The synthesis and use of 14C radiotracers)  European Pharmaceutical Contractor, Summer 2011
  • A Review of the Synthesis of Fluorine Substituted [Phenyl-U-14C]Aromatic Compounds, , 20th International Isotope Society UK Group Symposium,2011
  • Preparation of pyridazine derivatives useful as therapeutic cannabinoid receptor 2 agonists PCT Int. Appl. 2011, WO 2011097553 A1
  • Cellular basis for bimatoprost effects on human conventional outflow, Investigative Ophthalmology & Visual Science 2010;51(10),5176-81
  • Custom Carbon-14 Radiolabelling - Investing to Meet New Challenges Drug Discovery World Winter 2009/10, 53-60
  • Screening Technology For Fragment-Based Discovery sp2 November/December 2009, 22-23
  • Progress toward the Total Synthesis of Psymberin/Irciniastatin J. Org. Chem. 2009, 74, 5405-5410
  • Heterocyclic compound prostamide receptor antagonists 2008, US 20080096240 A1
  • Carbon-14 Synthesis using Microwaves, 16TH International Isotope Society (UK Group) Symposium Abstracts Journal of Labelled Compounds and Radiopharmaceuticals 2008, 51 247–261
  • The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products U.S. Pat. Appl. Publ. 2008 US2008096240
  • The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products Pharmacology & Therapeutics 2008, 120(1), 71-80
  • Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes British Journal of Pharmacology 2008, 154(5), 1079-1093
  • First Total Synthesis of 14C-Labeled Procyanidin B2 - A Milestone Toward Understanding Cocoa Polyphenol Metabolism European Journal of Organic Chemistry 2008, 6069-6078
  • Efficient and practical syntheses of a stable labelled form of the non-narcotic analgesic, bicifadine and its metabolites Journal of Labelled Compounds and Radiopharmaceuticals 2007, 50(2), 97-104
  • Preparation of abnormal cannabidiols as agents for lowering intraocular pressure U.S. Pat. Appl. Publ. 2007 US2007249596
  • Preparation of abnormal cannabidiols for use in opthalmic pharmaceutical compositions as agents for lowering intraocular pressure U.S. Pat. Appl. Publ. 2007 US2007249602
  • Preparation of abnormal cannabidiols as agents for lowering intraocular pressure U.S. Pat. Appl. Publ. 2007 US2007249581
  • Bimatoprost, prostamide activity, and conventional drainage Investigative Ophthalmology & Visual Science 2007, 48(9), 4107-15
  • Development of Ultrahigh-Throughput NMR Spectroscopic Analysis Utilizing Capillary Flow NMR Technology Analytical Chemistry  2005 77(13), 3947-3953